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Plot
Amber is a young woman who works at a butchery and dreams of escaping her small town existence and her alcoholic, widowed mother. Lately, meat and blood have started to upset her and her sleep is plagued by unsettling dreams in which she's either confronted by bloodthirsty creatures, or she runs at breakneck speed, something she excels at in everyday life, too. After learning she's been adopted, Amber decides to leave her old life behind and move to Chicago, but the owner of the apartment she plans to rent requires an advance deposit to be delivered before the following day at noon. Amber asks her best friend Susie to accompany her, and the road trip is eventually joined by Susie's boyfriend Peter, their friends Fiona and Ray, and Eric, a shy boy who's into Amber and contributes the means of transport for the group. Unfortunately, Eric's truck breaks down along the road. A friendly truck driver named Bernard stops by, and upon hearing he's also going to Chicago, Susie convinces him to give them a ride in the back of his semi, while Eric is selected to ride in the cabin with Bernard.
Amber and her friends become concerned when Bernard refuses to stop and they discover that his cargo consists of hundreds of cartons of blood. Concern turns into panic and terror when Bernard ends up taking them into an abandoned meat-packing plant that is soon revealed to be the training ground for a group of bloodthirsty creatures. Ray, Peter and Fiona are in turn attacked by the creatures, who dismember them. Amber and Susie manage to escape the first assault thanks to an improvised Molotov; while trying to reach a safe area, they stumble upon a wounded Eric, who's been taken from the truck's cabin to be used as bait. Amber tries to rescue Eric but he ends up thrown down a tall metal structure by the creatures, who possess a supernatural ability to run, climb and jump.
Amber and Susie overhear the leader of the creatures, Veronica, talking with her second-in-command and Bernard. Veronica refers to the creatures as her children, and aims to make them learn how to hunt human prey; to this goal, she has coaxed Bernard into helping her find fresh victims, which are usually junkies.
Following another attack, Amber and Susie are separated; Amber manages to pin down and interrogate one of the creatures, a young man who admits he's never hunted before, and tells Amber that Veronica is not their actual mother but she nonetheless takes care of them. In the end, Amber ends up surrounded by dozens of the creatures and by Veronica herself; trying to escape, she suddenly climbs up a wall in the same way the creatures do. Confused and frightened, she's recognized by Veronica as one of them, a "late bloomer" who was abducted by mistake. Veronica welcomes her warmly among her children, gives her some blood from the cargo, then offers her a captured Susie as her first true meal. Amber refuses to kill and eat her friend, and ignites a large gasoline spill, jumping away with Susie in her arms right in time to avoid the catastrophic conflagration.
Veronica orders the survivors to let Amber go, being sure she'll be back once she'll have accepted her true nature. Amber takes Susie to safety, then attacks and devours a homeless man who was going to assault Susie, while the latter watches in terror. After she's finished with her "meal", Amber reassures Susie she's still her friend and they'll be okay.
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