Iris is grieving for her young son Mateo, who died during a family hiking trip. She visits the site of his death and, inconsolable, considers jumping off a cliff. A man appears, who introduces himself as Richard, and after talking to him for a few minutes, Iris changes her mind. She follows Richard back to their parked cars. At the cars he attacks her with a stun device. Incapacitated, he then ties her wrists and ankles with zip ties before placing her in the back of his car.
Iris recovers consciousness as Richard is driving them to a remote cabin he knows, where he tells her they will have "all weekend" together. Iris uses her pocket knife to cut the tie on her wrists, and she attacks Richard, causing him to crash the car. The two fight briefly, but Iris manages to get out of the car and cut the tie securing her ankles. But Richard then shows her a syringe and tells her that during their skirmish he injected her with a paralysing agent, which will gradually render her helpless over the space of about 20 minutes.
Iris runs off into the woods, with Richard following at a leisurely pace, as he knows the injection will soon take effect. But as Iris slowly loses the use of her limbs, she makes it to a river and floats downstream on her back. Washing up further down the shore, she uses the last of her mobility to drag herself on to dry land.
Iris has landed on an isolated property belonging to an elderly man, Bill, who finds her as he is mowing his lawn. He and Iris manage to communicate with her blinking her eyes (once for yes, twice for no) in response to his questions. He takes her into his house and is about to call 911 when Richard turns up, this time introducing himself as "Andrew", and claiming to be looking for his wife. Bill does not mention Iris (who is lying behind the couch) as he doesn't trust Richard. He calls 911, but Richard attacks and kills him before setting the house on fire. Iris has begun to experience a return of mobility in her hands, and by pulling on the blind cord, she alerts Richard to her presence. He carries her out of the house and drives her away in Bill's truck, as a 911 response team speed towards the house.
Richard stops at a service station to refuel, and Iris - who is gradually recovering from the paralysis - unsuccessfully attempts to open the door of the truck. Richard drives back to his wrecked car to retrieve his property. While he is doing this, a police officer drives up and asks what's going on. Richard says his wife wrecked the car while drunk. The officer is unconvinced, and when he tries to talk to Iris, Richard kills him.
Richard transports himself and Iris to a small boat jetty, from which he intends to row Iris out to where he can dump her immobile body where he placed his earlier victims. But while in the boat, Iris is able to seize a knife, stab him through the neck, and push him overboard. He tries to climb back on to the boat, but Iris shoots him with his own gun, piercing the hull of the boat in the process. Despite the boat sinking, Iris manages to surface and swim to the jetty.
Further down the shore, Richard has dragged himself on to the bank. Iris stands over him as he dies, and thanks him, as during her struggle to escape from him she has rediscovered the will to go on living.
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